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  • ?ú?·基本信息

    ?ú?·名称:
    PLGA
    通用名:
     
    化学系列:
     
    浏览人次:
    3546
    发 布 者:
    sdsyxs
    发布日期:
    2011-04-13 15:37:23
    ?ú?·介绍
    ?ú????????????——
    ???¨?é?á-???ù???á?????????¨PLGA??
     
     
    ?????ú?·?é??
    ???¨?é?á-???ù???á?????????¨PLGA???????????ú???????????????????????????????ú???à?????????????ú???é?á?????ù???á?????????????????ú????×???????????????????±???????????
    PLA??PLLA?òPLGA——???úFDA???ú×??????¨?????¨?????ú??????????????
    ???ú?·??????????????
    ??    ???????????????????????¤???÷?????????·??
    ??    ·?×??????????????÷?????????????????¨??????????????3?ê????
    ??    ?á?§?????????????÷????????????????????
    ??    ??±???????????±??????????¤??????????·??±????
    ?????ú?·????
    ?????????¨?????ú????????????°ü?¨??
    ??    ????????????????????
    ??    ????????·ì????
    ??    ???¤???????????????¨°????????¤
    ??    ??????·??????¤
    ??    ×é???¤???§??——??°??à?????????ú?¤??
    ???????????????????????????ò×?????????×??????????????????????????¤?????é??????·??????????÷??????×é·???
    ??×?????????——Zoladex® ?¨Zenica??????????????
        ???????±??×??????¤???ò???????????±??1???????ù??PLGA??????????????????
    ?à?????ò×?????——LHRH?à???????ò?¨?????°????°???
    ?ú???????¨triptorelin??——·¨?úIpsen??????·???1986?ê????????????1??????
    ??±??????¨leuprorelin??——????1?????????ò×?????????±????????§??????????·??? 1989?ê???????ú??????
    ±?°±?????¨alarelin LHRH-A??——×?????????????????????????
    ???????ò×?????——??????×????????¨single dose vaccine??
    ????·??à?????¨tetannstoxoid,TT?????ò×???????????×????ó??????????????????·????????????????????ú?ú??????????????????
     
    ?????ú?·????

     

    ?ú?·????
    ??  ??
    ????????
    dl/g??
    ·?×???
    ?¨?ò??
    ??×ó??±?????  Poly-L-lactide

    PLLA

    0.5??6
    1??40
    ???é?á   Poly-DL-lactide
    PLA
    0.15??5
    0.5??40
    ???¨?é?á-???ù???á????????90/10
    Poly(DL-lactide-co-glycolide) 90/10
    PLGA 90/10
    0.15??2.5
    0.5??20
    ???¨?é?á-???ù???á????????80/20
    Poly(DL-lactide-co-glycolide) 80/20
    PLGA 80/20
    0.15??1.5
    0.5??15
    ???¨?é?á-???ù???á????????75/25
    Poly(DL-lactide-co-glycolide) 75/25
    PLGA 75/25
    0.15??1.5
    0.5??15
    ???¨?é?á-???ù???á????????70/30
    Poly(DL-lactide-co-glycolide) 70/30
    PLGA 70/30
    0.15??1.2
    0.5??12
    ???¨?é?á-???ù???á????????60/40
    Poly(DL-lactide-co-glycolide) 60/40
    PLGA 60/40
    0.15??0.9
    0.5??10
    ???¨?é?á-???ù???á????????50/50
    Poly(DL-lactide-co-glycolide) 50/50
    PLGA 50/50
    0.15??0.8
    0.5??10
    *???????????¨?????????????????×?é??????25±0.05 ????
    *PLGA??????????PLGA 75/25??PLGA 50/50???????ü±????ú?·?è??????

     

     
    ?????ú?·????
    ???é?á?¨PLA??PLLA???????¨?é?á-???ù???á?????????¨PLGA???ú?·????°ü?¨??
    ???????¨???????ì?é?????ú???????????????ì?é
    “?????¨??”?????ì?é??
    ?????????ú?????·2000?ê°????ú?????à?ú?·???????ó????±??·?????????ì?é??
    ????×??? ±??·???????×?é????·??ò±??????×???????????ò??????????
    ????±???
    ?¨1??±??·???ì?????ü?????×???????·?????×??????
      ?¨2??±??·??1H???????????×???????·?????×??????
    ???ì?é?? ?????????ú????2000?ê°??????????·?????à?????ó????±??·???????á?????????§??????×????ü???????????é???????????°???ú???????????ì?é????±í1??
     
    ±í1??PLGA?÷???ì?é?????¨?á??
    ?ú??
    2003111205
    2003111801
    2003111802
    ?á??
    4.90
    4.31
    4.83
    ????%
    0.005
    0.006
    0.006
    ???á????%
    0.014
    0.013
    0.017
    ?????×?é%
    0.042
    0.043
    0.058
    ?????§??%
    0.5449
    0.5010
    0.4785
    ??×????ü%
    0.1533
    0.1449
    0.1318
    ??????
    < °??ò·?????
    < °??ò·?????
    < °??ò·?????
    ?é??%
    0.00002
    0.00002
    0.00002
    ????%
    0.0080
    0.0025
    0.0082
     
    ?¤??  ?????¤??·¨???¨??[η]??0.14??2.5 dl/g?¨??·???25±0.05??????
    ?????×?é?????á??????????  ?????ú?????????????¨·¨?¨???ú????2000?ê°???????????P????·¨?????¨?????????×?é??????????0.06%?????????????á?????????ù??????0.5%??
    ????????×é?????¨?? ????PLGA??????1H?????????×?¨1H NMR????????·?±????ó????????×é??????±??¨LA/GA??90/10??50/50????
    ??·?×??????¨??  ?????????????×?ù????·????÷???à???ù????30?????????????????ì???÷??±ê?ù??????·?×?????????±???????????GPCר???í??????±ê×??ú?????????í??????????·?×????°·?×???·????¨Mw??5000??200000??Mw/Mn??1.2??2.0????
    ??????????????  ???????ò·?×????????????????????????????ù????????????